AVF Science Session I: Genetics, COVID and Vein Biology Abstracts
Genetics of Venous Ulceration
A study of single nucleotide polymorphisms in patients with C5 and C6 disease found GP6 and MMP12 protective against venous stasis ulcer formation, while factor 13 A1, SLC40A1, and the hemochromatosis gene HFE were associated with ulcer persistence.
Coronavirus and Endothelial Injury
A mouse model of coronavirus infection showed that macrophage expression of the histone methyltransferase MLL1 drives inflammatory cytokine output and soluble E-selectin release, and that patients who died in the ICU had higher circulating E-selectin levels.
Lymphatic Glycocalyx and Vein Wall Genes
Electron microscopy of harvested lower limb tissue produced the first identification of a glycocalyx like structure in human lymphatics, and RNA sequencing of varicose versus non varicose vein segments identified PSMA7 and DUSP4 as candidate regulators of varicose vein gene expression.
AI Mapping of Vein Valve Degeneration
An artificial intelligence model analyzed thousands of ultrasound recordings from over a thousand legs to distinguish embryonic vein lesions, pressure induced valve decompensation, and stasis related degeneration, reconstructing a longitudinal timeline of vein valve damage from childhood through adulthood.
Post Tags
- Artificial Intelligence Diagnostics
- Basic Science Research
- Coronavirus Coagulopathy
- Endothelial Injury
- Lymphatic Glycocalyx
- RNA Sequencing
- Single Nucleotide Polymorphisms
- Ultrasound Analysis
- Varicose Vein Gene Expression
- Vein Valve Degeneration
- vein wall biology
- Venous Ulcer Genetics show moreshow less
